5'-O-Monophosphoryladenylyl(2' goes to 5')adenylyl(2' goes to 5')adenosine is an antagonist of the action of 5'-O-triphosphoryladenylyl-(2' goes to 5')adenylyl(2' goes to 5')adenosine and double-stranded RNA.
Open Access
- 1 October 1981
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 78 (10) , 5993-5997
- https://doi.org/10.1073/pnas.78.10.5993
Abstract
5''-O-monophosphoryladenylyl(2'' .fwdarw. 5'')adenylyl(2'' .fwdarw. 5'')adenosine [(2'' .fwdarw. 5'')(pA)3] antagonizes the protein synthesis inhibitory effects of 5''-O-triphosphoryladenylyl(2'' .fwdarw. 5'')adenylyl(2'' .fwdarw. 5'')adenosine by preventing activation of the (2'' .fwdarw. 5'')oligo(A)-activated RNase which degrades mRNA. The oligoribonucleotide (2'' .fwdarw. 5'')(pA)3 also antagonizes the translational inhibitory capacity of poly(I .cntdot. C) in extracts of interferon-treated [mouse] L cells, suggesting that (2'' .fwdarw. 5'')oligo(A) is the primary mediator of the protein synthesis inhibitory effects of poly(I .cntdot. C) in this cell-free system.This publication has 41 references indexed in Scilit:
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