A single-blind comparative study of once daily dothiepin (‘Prothiaden’) and divided daily doses of amitriptyline
- 1 January 1976
- journal article
- clinical trial
- Published by Informa Healthcare in Current Medical Research and Opinion
- Vol. 4 (6) , 416-421
- https://doi.org/10.1185/03007997609111997
Abstract
Forty-eight patients took part in a single-blind clinical trial comparing a once daily dose of dothiepin (75 mg) and 25 mg 3-times a day of amitriptyline. The results showed that dothiepin caused a greater improvement than amitriptyline after 4 weeks of treatment as judged by depression scores, total scores and global assessments. The incidence of side-effects was less with dothiepin and in those patients who actually reported side-effects the severity was much less with dothiepin than with amitriptyline.Keywords
This publication has 6 references indexed in Scilit:
- An Evaluation of a Once Daily Dosage Régime of Dothiepin Hydrochloride (Prothiaden)Journal of International Medical Research, 1976
- The Hamilton Rating Scale. An Assessment Based on a Dothiepin (‘Prothiaden’) versus Imipramine (‘Tofranil’) Clinical TrialInternational Pharmacopsychiatry, 1975
- A General Practitioner Study of Dothiepin and AmitriptylineJournal of International Medical Research, 1974
- A Double-Blind Comparison of Three Times Daily and Single Night Dosage of the Tricyclic Anti-Depressant DothiepinJournal of International Medical Research, 1974
- A Brief Rating Scale for antidepressant drug trialsComprehensive Psychiatry, 1971
- A double-blind comparison of dothiepin and amitriptyline for the treatment of depression with anxietyPsychopharmacology, 1971