Effects of Seasonal Heat Stress on Glomerular and Tubular Functions in the Dog

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Abstract
Clearance studies in the unanesthetized dog revealed statistically significant depressions in the TmG and GFR under conditions of seasonal heat stress. These depressions were no longer present with the advent of temperate environmental conditions. The changes in Tmg are dependent on changes of the GFR. Computations of coeffs. of correlation (r) based on 246 clearance periods performed on 7 dogs yielded a mean r of 0.561 which was highly significant (P <0.01). Simultaneous depressions of both TmG and GFR observed in these experiments can be most plausibly explained by the concept of intermittence of nephron activity. It is postulated that environmental heat stress in some unknown way decreases the number of functioning nephrons in the dog.
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