Simultaneous measurements of acetaminophen and salicylate in plasma by liquid chromatography.
Open Access
- 1 June 1979
- journal article
- research article
- Published by Oxford University Press (OUP) in Clinical Chemistry
- Vol. 25 (6) , 1002-1004
- https://doi.org/10.1093/clinchem/25.6.1002
Abstract
We describe a "highly-performance" liquid chromatographic method in which 8-chlorotheophylline is used as an internal standard to determine acetaminophen and salicylate simultaneously in plasma samples. Therapeutic as well as toxic concentrations can be determined on samples as small as 50 micro L, which makes the method particularly useful for determinations on samples from young children. The procedure requires a simple extraction of the drugs, and the chromatography is completed in 6 min.This publication has 5 references indexed in Scilit:
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- GLC Microanalyses of Phenacetin and Acetaminophen Plasma LevelsJournal of Pharmaceutical Sciences, 1977
- Determination of acetaminophen and phenacetin in plasma by high-pressure liquid chromatography.Clinical Chemistry, 1977
- Acetaminophen in Serum and Plasma Estimated by High-Pressure Liquid Chromatography: A Micro-Scale MethodClinical Chemistry, 1977
- Rapid determination of salicylate in biological fluidsBiochemical Journal, 1954