EFFECT OF METOPIRONE IN A PATIENT WITH ADRENAL CORTICAL CARCINOMA

Publisher Website
Google Scholar
Abstract
The effect of metopirone (SU-4885f in a patient with metastatic adrenal cortical carcinoma was studied. The intention was to depress the symptoms of Cushing''s syndrome, due to a high glucocorticoid production by the carcinoma. The excretion of 17-KS, 17-KGS, ll-oxo(y)-17-OHCS and 11-desoxy-17-OHCS was followed for seven weeks. The steroid excretion was variable. The ll-oxo-(y)-17-OHCS showed a significant decrease during treatment with SU-4885 for seven weeks. The ratio ll-oxo(y)-17-OHCS: ll-desoxy-17-OHCS fell from 1.7 to 0.1 during this period. The excessive glucocorticoid production of the metastatic adrenal carcinoma was suppressed as long as treatment continued. It was not possible to judge the clinical effect of SU-4885 because of the progressive nature of the disease.