Strand scission in DNA induced byl-DOPA in the presence of Cu(II)
- 1 May 1995
- journal article
- Published by Wiley in FEBS Letters
- Vol. 364 (1) , 75-78
- https://doi.org/10.1016/0014-5793(95)00365-g
Abstract
It has been recently reported that l-DOPA and Cu(II) in the presence of H2O2 leads to extensive DNA damage. In this paper we show that l-DOPA in the presence of Cu(II) alone can cause DNA cleavage through the generation of reactive oxygen species such as the hydroxyl radical. Fluorescence quenching studies indicate that l-DOPA is capable of binding to DNAKeywords
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