Steroid Metabolites from Cholesterol-C14in a Patient with Adrenal Cancer: Effects of Metopirone

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Abstract
The urinary steroid metabolites following the injection of C14-cholesterol before and after the administration of Metopirone to a female patient with an adrenal cancer were isolated and identified. The injected C14-cholesterol was excreted in the urine at a low but constant rate for at least 80 days following the injection of the sterol. The 11-oxygenated steroid disappeared from the urine following the administration of Metopirone; the only corticosteroid metabolites isolated from the urine were those of 11-deoxycortisol. The results of the study indicate that Metopirone inhibited 11-hydroxylation in the cancerous tissue. 6β-Hydroxyandrostenedione was also isolated; this appears to be the first description of its presence in human urine.