Clotting Factors and Platelets
- 1 January 1977
- journal article
- research article
- Published by S. Karger AG in Pathophysiology of Haemostasis and Thrombosis
- Vol. 6 (3) , 171-179
- https://doi.org/10.1159/000214177
Abstract
Factor I (fibrinogen) and factor VIII were shown, by an indirect immunofluorescence technique, to be present in human washed platelets. In the case of fibrinogen, the immunofluorescent pattern had a ‘clod distribution’ up to a 1:128 dilution of the antiserum. Factor VIII showed a ‘speckled’ pattern up to the 1:64 dilution. Cross-absorption studies confirmed the presence of such factors. Factor II, VII, IX, X and XIII, however, were not found in washed platelets. A diffuse fluorescence was noted using normal rabbit sera, but this was due to a cross-reaction, since it disappeared using a 1:32 diluted sera.Keywords
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