Comparative Studies on LS Antigens Induced by Vaccinia and Cowpox Viruses

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Abstract
The constituents of LS antigen from [rabbit kidney RK-13] cells infected with vaccinia virus and with cowpox virus were compared by immunoprecipitation and SDS[sodium dodecyl sulfate]-polyacrylamide gel electrophoresis. Antiserum to the LS antigen from cells infected with vaccinia virus reacted with at least 5 polypeptides in cells infected with either virus. Four of these polypeptides were similar sizes in cells infected with the 2 viruses. One major polypeptide with a MW of about 100,000 (100 K [kilodalton]) detected in cells infected with vaccinia virus was not found in cells infected with cowpox virus. Conversely, a polypeptide with a MW of about 60,000 (60 K) was detected only in cells infected with cowpox virus.