THE ADRENOCORTICAL RESPONSE TO ACTH, CORTISONE AND ASCORBIC ACID IN CHILDREN A COMPARISON WITH THE RESULTS OBTAINED IN ADULTS

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Abstract
In 15 children the admn. of ACTH caused an increase of urinary-reducing neutral steroids (corticoids) comparable to that of adults. The 17-ketosteroid response, however, was much less than seen in adults. Urinary corticoids are therefore a better index of ACTH response than 17-ketosterotds in children. Most of the increase of 17-ketosteroids in children probably comes from conversion of corticoids. The addition of cholesterol did not affect the results; however, the additional admn. of ascorbic acid caused an initial fall of corticoid excretion in 8 of 10 cases, followed by a compensatory rise, so that corticoid excretion over the exptl. period was unaffected.