Growth and production of anthracyclines in wild-type and mutant strains ofStreptomyces galilaeus

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Abstract
The course of growth curves with respect to the biosynthesis of anthracyclines was followed in the wild low-producing strainStreptomyces galilaeus JA 3043 and in its mutants G-167 (producing increased quantities of glycosides of ε-pyrromycinone) and J-14 (accumulating free ε-pyrromycinone). A two-phase type of fermentation (growth phase, production phase) was observed in strains JA 3043 and J-14. The maximum production of anthracyclines occurred only after the end of intense growth of the culture. Two phases of rapid growth separated by a phase of stagnation were observed in strain G-167. The second growth phase proceeded only during late hours of cultivation and was (as compared with the first phase) associated with an intensive biosynthesis of anthracyclines.