THE PREPARATION AND PROPERTIES OF UROGASTRONE1

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Abstract
UROGASTRONE is a watersoluble substance, obtainable from the urine of both dogII I and man, which effectively inhibits gastric secretion (1, 2, 3). Its physiological rôle has not been elucidated as yet, but in the course of preparing and assaying several hundred preparations of urogastrone, some information regarding its chemical and physiological properties has been obtained. It is the purpose of this report to communicate these findings and to describe methods for obtaining the principle in highly potent form. Crude concentrate. The urine is collected in 5gallon bottles containing sufficient preservative to maintain sterility when the bottle has become filled. In the case of tricresol a concentration of 0.25‰ is used; with phenol, a concentration of 0.5‰, with toluene, enough is used to cover the surface. If the latter preservative has been used, the urine without stirring is siphoned off to separate it from the toluene,

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