d-Aminosäureoxydase-Wirksamkeit in Leberextrakten von kachektischen und trächtigen Ratten

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Abstract
To produce a state of cachexia, rats 150-300 g. in weight are treated with 2-3 mg. dichlorodiethylsulfide at intervals of 3-4 days, the total amt. of the compound, which is applied to the skin on their backs, being 10-20 mg. The rats lose 30-50 g. in weight and some of them die. The d-amino acid oxidase of their liver extracts is detd. as descr. previously (Hoppe-Seyler''s Zeitschr. Physiol. Chem., 281: 89-93, 1944), and it is found that the enzyme is not decreased in the livers of these rats in comparison to normal livers. Neither is the d-amino acid oxidase decreased in the livers of animals suffering from burns. Pregnant rats 180-300 g. in weight are sacrificed shortly before the birth of the young. The O2 consumption of the extract prepared from their livers is 25 cmm. in 1 hr., while the corresponding consumption of the extract of livers of control rats is 70 cmm. There is no change in the liver proteins of the pregnant rats, the % total protein, albumin, globulin and total N for their livers being, respectively, 13.3, 3.3, 10.0 and 2.88, while the corresponding values for normal livers are 13.1, 3.0, 10.1 and 2.89. There is not a specific correlation between the presence of malignant growths and a decrease of d-amino acid oxidase in the liver. The decrease of the enzyme is associated with either benign or malignant great cell growth.

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