Hormonal inducibility of rat α2u globulin genes in transfected mouse cells
- 1 June 1981
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 291 (5817) , 629-631
- https://doi.org/10.1038/291629a0
Abstract
Two different genes, coding for the hormonally regulated rat liver protein .alpha.2u globulin, were introduced into mouse Ltk- cells through cotransfection with the HSV-1 [herpes simplex virus type 1] thymidine kinase gene. Copies of the .alpha.2u globulin genes [3-10] were detected in several tk+ clones, over 50% of which could be induced with dexamethasone to produce .alpha.2u globulin mRNA and protein. The information necessary for hormonal response evidently is contained in the DNA fragment used for transfer.Keywords
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