RESPONSE OF THE ALKALINE PHOSPHATASE OF THE ADRENAL CORTEX OF THE MOUSE TO ANDROGEN1

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Abstract
Alkaline phosphatase is present in marked conc. in the nuclei and cytoplasm of the fascicular and re-ticular zones of the adrenal cortex of the adult [male] mouse. It is absent, or present only in traces, in the normal [female], the ovariectomized [female], the castrated [male] and the immature [male]. Its first appearance in the d1 is concurrent with the regression of the X-zone. Treatment with testosterone propionate results in the appearance of alkaline phosphatase in the adrenal cortex of the castrated [male] the ovariectomized [female] and immature animals of both sexes. The alkaline phosphatase of the adrenal cortex of the mouse is under the control of androgen. The glomerulosa differs from the fasciculata in its inability to acquire this enzyme through androgenic stimulation. The mobilization of cortical alkaline phosphatase by androgen provides another link in the chain of reactions associated with the physiology of androgens and of the adrenal cortex.

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