ERYTHROCYTE PRESERVATION. VII. ACID-CITRATE-DEXTROSE-INOSINE (ACDI) AS A PRESERVATIVE FOR BLOOD DURING STORAGE AT 4° C1

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Abstract
The relative order of activity of purine nucleosides in the regeneration of phosphorylated esters of stored erythrocyte was established as follows: inosine > adenosine > guanosine > xanthosine. The utilization of adenosine by the red cell involves an initial conversion to inosine, and the subsequent purine metabolite is hypoxanthine. The plasma of blood stored in acid-citrate-dextrose-inosine (ACDI) contains increasing amounts of hypoxanthine during storage. Intravenous administration of inosine or hypoxanthine has only a questionable hypoten-sive effect in comparison with the pronounced hypotensive properties of adenosine. The post-transfusion survival of cells stored in ACDI for 6 to 7 weeks is about 82% as indicated by the differential agglutination and Cr51 techniques.