Antimicrobial Peptides in the Skin
- 23 January 2003
- journal article
- letter
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 348 (4) , 361-363
- https://doi.org/10.1056/nejm200301233480418
Abstract
Ong et al. (Oct. 10 issue)1 described a lack of induction of human β-defensin 2 (HBD-2) and the cathelicidin LL-37 in atopic skin disease as compared with psoriasis, yielding a plausible explanation for the superinfection by gram-positive strains seen in neurodermatitis. In the accompanying editorial,2 Zasloff asks whether other disorders may also be related to a defensin deficiency; Crohn's disease, in contrast to ulcerative colitis, may be due to deficient induction of HBD-2.3,4Keywords
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