Effects of Cortisone and Herpes Simplex Virus on Metabolic Processes. I. Alterations in HeLa Cell Metabolism.

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Abstract
HeLa cells infected with herpes simplex virus produced more organic acids than uninfected control cultures when glucose was the principle substrate. Infected cells grown with cortisone formed as much lactic acid as infected cells grown in the absence of cortisone, but in addition, the former cells produced large amounts of acetate, pyruvate and another compound tentatively identified as succinate. Glucose utilization was stimulated by virus and cortisone in the HeLa cell system resulting in the accumulation of Krebs cycle intermediates. Concomitant with marked acid production definite cytopathogenicity and increase in virus titers occurred in the virus-infected cultures.