Demonstration of Two Effects of Cortisone on Virus-Cell Interaction

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Abstract
Cortisone in a concentration of 0.25 mg/ml produced a delay and partial inhibition of cytopathogenic (CP) changes when introduced into HeLa cell cultures at the time of injection with poliomyelitis virus Types I and II and with vaccinia virus. This substance appears to have no effect on the virus in the absence of living cells. When cortisone in the same concentration was added to actively growing HeLa cells and then washed away prior to infection, it accelerated the CP changes when cells were subsequently infected with poliomyelitis virus Types I and II.