THE EFFECT OF HYPOPHYSECTOMY AND OF TSH ON THE MOUSE SUBMAXILLARY IODIDE PUMP1

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Abstract
The I131 that is concentrated by the submaxillary glands of mice injected with radioiodide remains in the form of inorganic iodide, as revealed by paper chromatography and paper electrophoresis. The iodine concentrating capacity of submaxillary gland tissue in three strains of mice was determined by measuring the ratio, I131 concentration in submaxillary to radioiodide concentration in plasma, (S/P ratio), at various intervals after I131 injection. S/P ratios ranged from values of 4 to 7 for C3H and Webster-Swiss mice to values of more than 30 for Cal A mice. In the former groups the maximum ratio was reached in about one hour, in the latter, after 4 hours. Hypophysectomy and TSH injections did not induce any significant change in S/P ratios although, in the same mice, thyroid I131 uptakes or T/S ratios were markedly affected. It is concluded that the submaxillary iodide pump, unlike the thyroid iodide pump, is not directly affected by the presence or absence of TSH. These observations are discussed in relation to a previously proposed mechanism of action of TSH on the thyroid gland.