SYMPTOMS AND ETIOLOGY OF THE STEIN-LEVENTHAL SYNDROME

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Abstract
Two main types are distinguished. The first group (type 1) was characteristized by ovarian activity and an androsterone/etiocholanolone ratio that was > 1. The second group (type 2) was characterized by an absence of signs of ovarian function and an androsterone/etiocholanolone ratio that was[image] 1. The interpretation given to these findings is that in type 1 the masculinizing factor originates in the ovaries, possibly in the stroma, in which there was positive lipid straining, whereas in type 2, owing to inactivation of the ovaries, the hypophyseal gonadotropin acts on some other gland, most probably the "sexual zone" of the adrenal cortex, which then serves as the source of the masculinizing factor.