Effect of oestradiol-17β on uterine epidermal growth factor concentration in immature mice

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Abstract
Using a specific and sensitive epidermal growth factor radioimmunoassay (EGF-RIA) EGF was identified in immature mouse uterine tissue. In 16 day old mice a single injection of estradiol-17.beta. (E2) elicited an increase in uterine wet weight in 24 h but did not affect uterine EGF concentration. Sequential injection of E2 for a 7 day period increased both uterine wet weight and EGF concentration suggesting that change in EGF concentration is a delayed E2 response. The continuous treatment did not alter liver or submandibular gland tissue EGF concentrations but significantly increased kidney EGF content. Both uterine and renal tissue EGF concentrations are subject to modulation by E2 in developing mice.