Gas Chromatography of Nickel

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Abstract
A gas chromatographic method has been developed lor the detection of nickel carbonyl in blood and breath. Nickel carbonyl has been identified in blood following exposure of rats to nickel carbonyl by inhalation. Nickel carbonyl has also been identified in breath following administra" tion of nickel carbonyl to rats by intravenous injection. Therefore, this study has demonstrated that nickel carbonyl can pass across the pulmonary alveolus in either direction, without degradation or metabolic alteration. The gas chromatographic method is suggested as a technique for monitoring the concentrations of nickel carbonyl in industrial atmospheres and in the blood of workmen who are accidentally exposed to inhalation of nicke! carbonyl.