THE PRODUCTION OF IMMUNO-CONGLUTININ: VI. THE EFFECT OF ADJUVANT ON THE STIMULATION OF IMMUNO-CONGLUTININ PRODUCTION

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Abstract
The production of immuno-conglutinin can be stimulated by (1) the injection of a heterologous complement absorbed on an antigen-antibody complex or on certain active surfaces (heterostimulation) or (2) any strong antigenic challenge (autostimulation). The incorporation of these antigens in adjuvants increases and prolongs the production of immuno-conglutinin in response to heterostimulation but decreases the immuno-conglutinin response to autostimulation. Adjuvant alone, kaolin in adjuvant, or kaolin treated with heated serum in adjuvant do not stimulate the production of immuno-conglutinin.In heterostimulation experiments, the intramuscular route of inoculation stimulates the highest and most prolonged high titers of immuno-conglutinin. The intravenous route of inoculation stimulates high titers of immuno-conglutinin but the level of activity decreases quite markedly over the period of 30 weeks.