EFFECTS OF LYMECYCLINE ON MYCOPLASMA-PULMONIS-INDUCED ARTHRITIS IN MICE

  • 1 January 1978
    • journal article
    • research article
    • Vol. 59  (2) , 204-212
Abstract
The effect of lymecycline treatment on arthritis in C3H mice produced 5 mo. previously by i.v. inoculation of M. pulmonis was examined. Treatment had little effect on the severity of the clinical disease. There was a marked reduction the severity of the histopathological inflammatory reaction in joints from lymecycline-treated mice when compared with untreated controls. This reduction was associated with eradication of viable mycoplasmas from the joints. Persistent arthritis in C3H mice may be due to the continued presence of viable M. pulmonis organisms in the joint tissues.