BISPHOSPHONIC COMPOUNDS. IV.1PREPARATION AND IDENTIFICATION OF MIXED TETRAALKYL METHYLENE- AND (DICHLOROMETHYLENE)-BISPHOSPHONATES BY NMR SPECTROSCOPIC, MASS SPECTROMETRIC AND X-RAY CRYSTALLOGRAPHIC STUDIES
- 1 January 1992
- journal article
- research article
- Published by Taylor & Francis in Phosphorus, Sulfur, and Silicon and the Related Elements
- Vol. 70 (1) , 183-203
- https://doi.org/10.1080/10426509208049167
Abstract
The chemistry of 28 mixed tetraalkyl methylene- and (dichloromethylene)bisphosphonates, (R1O)(R2O)P(O)CX2P(O)(OR3)(OR4), where R1=Et, Allyl, CH=CHMe, Pri, Bu, But, Hex, Ph, Bn or octadecyl, R2=Me, Et, Pri, Bu, But, Hex, Ph or Bn, R3=R4=Me, Et, Pri or Ph and X=H or Cl, have been studied. 1H, 13C, 31P NMR data are reported, including 1JCH, 3JCP, 3JCP and 2JPP coupling constants. The fragmentation of some representative compounds were studied in the gas phase. The solid state structure is given for (PhO)2P(O)CH2P(O)(OMe)2.Keywords
This publication has 29 references indexed in Scilit:
- Long-lived radical cations of simple organophosphates isomerize spontaneously to distonic structures in the gas phaseJournal of the American Chemical Society, 1992
- Bisphosphonic Compounds. II. Preparation of Monophosphonic Starting Materials. Mixed Esters of Methylphosphonic AcidSynthetic Communications, 1992
- New Synthesis of Phosphorous and Phosphoric Acid EstersSynthesis, 1991
- THE REACTION OF ALKANEPHOSPHONIC ACID ESTERS WITH METALSPhosphorus, Sulfur, and Silicon and the Related Elements, 1989
- HOFMANN ELIMINATION REACTION WITH PHOSPHORUS CONTAINING ALKYLAMMONIUM SALTSPhosphorus and Sulfur and the Related Elements, 1988
- SYNTHESIS OF α-HALOGENATED METHANEDIPHOSPHONATES1a, bPhosphorus and Sulfur and the Related Elements, 1988
- Synthese von phenoxygruppenhaltigen Derivaten der MethandiphosphonsäureZeitschrift für anorganische und allgemeine Chemie, 1986
- A new class of potential photoaffinity labels. .alpha.-Diazophosphonic acids: synthesis and stabilityJournal of the American Chemical Society, 1977
- Carbon-13 nuclear magnetic resonance of organophosphorus compounds. I. Diethyl phosphonatesJournal of the American Chemical Society, 1971
- Synthesis and properties of mono- and poly-methylene-diphosphonic acids and estersJournal of Inorganic and Nuclear Chemistry, 1961