Transcription factor GATA‐1 in megakaryocyte development

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Abstract
The transcription factor GATA‐1 is specifically expressed in hematopoietic lineages. Prior gene knockout experiments established an essential role for GATA‐1 in red blood cell production, but could not provide direct evidence with respect to a requirement in megakaryopoiesis. We summarize here recent lineage‐selective gene targeting in mice that establishes critical functions for GATA‐1 in controlling megakaryocyte growth and maturation, and platelet production. GATA‐1 megakaryocytes are delayed in their cellular maturation, exhibit marked hyperproliferation and generate fewer than normal, yet enlarged, platelets in vivo. Thus GATA‐1 is a central regulator in both the erythroid and megakaryocytic lineages.