Comparison of the Intravascular Mixing and Disappearance of Radiosodium, Radiopotassiuin and T-1824

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Abstract
A method is presented utilizing the rapid intravenous injection of a dye-isotope mixture and rapid, serial arterial sampling which permits the determination of rates of disappearance of these materials from the vascular system. Since K+ traverses capillary endothelial walls at about twice the rate of Na+ it appears that these two ions, while being about the same size and having the same charge, are handled in different manners by the capillaries. Other variables obtainable from the T-1824 isotope time-concentration curves such as plasma volume, circulation time, cardiac output and isotope distribution volumes are also presented.

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