The Relationship of the Normal and Hyperactive Ovary to Menstruation and to Endometrial Hyperplasia1

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Abstract
This paper begins with a review of the recent studies on the physiology of menstruation, particularly the observations of Markee on intraocular endometrial transplants in the monkey, in which the behavior of the spiral arteries was for the first time seen. The endocrine relations in this behavior are dis- cussed and an attempt is made to apply the physiologic findings to the pathology of the endometrium, particularly to hyperplasia and its frequent accompaniment, metror-rhagia. A parallel is drawn between cystic ovaries (produced by resection of ovarian tissue after the method of Lip-schiitz) and hyperplasia in the guinea pig, spontaneous cystic ovaries and nymphomania in cows and cystic ovaries and hyperplasia in women. It is suggested that perhaps the cow might constitute the animal of choice for expts. along these lines; for once the cause of hyperplasia becomes known rational means of therapeutics will be at hand.