Influence of the Tonicity of Body Fluids on Rate of Excretion of Electrolytes

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Abstract
Dilution of the body fluids induced with a positive balance of water promotes a decrease in the rates of excretion of Na, chloride and K, and an increase in the rate of excretion of ammonia. Part of the decrease in the rate of excretion of NaCl is probably due to an increase in the renal tubular reabsorption of these ions. The stimulus for this increase in tubular activity may be the decrease in effective osmotic pressure of the extracellular fluid or the associated overhydration of cells. However, it is conceivable that the stimulus was the decrease in the concn. of Na per se. The diminished excretion of K may also be a reflection of cellular overhydration. The higher rate of excretion of ammonia in the dilution studies is interpreted as a consequence of the lower rate of excretion of N and K.

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