Oligonucleotide fingerprint analysis of enterovirus 70 isolates from the 1980 to 1981 pandemic of acute hemorrhagic conjunctivitis: evidence for a close genetic relationship among Asian and American strains

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Abstract
Enterovirus 70 isolates obtained in Asia and America beween 1980 and 1981 from cases of acute hemorrhagic conjunctivitis were closely related by RNase T1 oligonuleotide fingerprinting. Two closely related isolates from the 1st acute hemorrhagic conjunctivitis epidemic (1969-1972) differed by many oligonucleotides from the 1980-1981 pandemic strains. The strong similarities of oligonucleotide patterns of isolates from the same epidemic, but from distant regions of the world suggest that the genome of enterovirus 70 tends to be conserved during natural infection, a possible consequence of the transient nature of the disease.