Resistance to a Malignant Lymphoma in Chickens Is Mapped to Subregion of Major Histocompatibility ( B ) Complex
- 25 February 1983
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 219 (4587) , 977-979
- https://doi.org/10.1126/science.6823560
Abstract
A genetic recombinant within the major histocompatibility (B) complex of the chicken has revealed the chromosomal subregion effecting resistance to Marek's disease--a malignant lymphoma induced by a herpesvirus. The recombinant, BF21-G19, occurred spontaneously among the progeny of a male heterozygous for resistant BF21-G21 and susceptible BF19-G19 haplotypes. Exposure to Marek's disease of families segregating for the recombinant showed that this new F-G arrangement conferred a level of resistance equivalent to that of the resistant parental haplotype. Thus, a gene, or genes, within or closely linked to the B-F region of the B complex appears to be responsible for the observed resistance to Marek's disease.This publication has 14 references indexed in Scilit:
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