Does Nitrous Oxide Affect the Hemodynamic Effects of Anesthesia Induction with Propofol?

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Abstract
Anesthesia was induced in 20 patients, ASA physical status I and II, with either propofol (2.5 mg .cntdot. kg-1), vecuronium (100 .mu.g .cntdot. kg-1), and 100% oxygen (Group A), or with equal doses of propofol and vecuronium but with 70% nitrous oxide in oxygen (Group B). All patients were premedicated with lorazepam 2 mg orally. In both groups systolic arterial pressure decreased after 3 minutes (P < 0.05) due to decreases in cardiac output and stroke volume (P < 0.05). Systemic vascular resistance in both groups did not change immediately after administration of propofol but increased (P < 0.05) following intubation. Addition of nitrous oxide did not alter hemodynamic parameters associated with propofol induction.