Cloning and expression of R-Spondin1in different vertebrates suggests a conserved role in ovarian development
Open Access
- 24 July 2008
- journal article
- Published by Springer Nature in BMC Developmental Biology
- Vol. 8 (1) , 72
- https://doi.org/10.1186/1471-213x-8-72
Abstract
R-Spondin1 (Rspo1) is a novel regulator of the Wnt/β-catenin signalling pathway. Loss-of-function mutations in human RSPO1 cause testicular differentiation in 46, XX females, pointing to a role in ovarian development. Here we report the cloning and comparative expression analysis of R-SPONDIN1 orthologues in the mouse, chicken and red-eared slider turtle, three species with different sex-determining mechanisms. Evidence is presented that this gene is an ancient component of the vertebrate ovary-determining pathway.Keywords
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