Cadmium enhancement of proximal tubular sodium reabsorption

Publisher Website
Google Scholar
Abstract
Stop-flow studies were performed to localize the site of cadmium action on renal sodium reabsorption. In the untreated dog undergoing mannitol diuresis, a maximal lumen:plasma sodium gradient was established across the proximal tubule during free flow with no further lowering of luminal concentration during ureteral occlusion, Naprox/NaFF = 1.02 ± .05. During occlusions after cadmium, sodium concentrations in proximally trapped fluid were reduced below free-flow values, Naprox/NaFF = 0.85 ± .08. This difference between treated and untreated animals was statistically significant (P = < .001) and indicates that cadmium enhances proximal sodium reabsorption. Although distal sodium patterns were unaltered by cadmium, it was not possible to rule out a possible distal site since distal sodium reabsorption is already virtually complete during occlusion in the untreated animal. Cadmium, given intravenously as Cd115, was not excreted in the urine.

This publication has 11 references indexed in Scilit: