THE EFFECT OF VARIATIONS IN SOLUTE EXCRETION AND GLOMERULAR FILTRATION ON WATER DIURESIS 1

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Abstract
Maximal sustained water diuresis was produced in 29 experiments in 17 normal semi-recumbent subjects, and the effects of physiological variations in the dietary intake and urinary excretion of solutes and in glomerular filtration rate (GFR) (endogenous creatinine clearance) upon maximal urinary flow, free water clearance and minimal urinary osmolarity were evaluated. The magnitudes of the maximal urinary flow, free water clearance and minimal urinary osmolarity were directly correlated with the rate of solute excretion. GFR (endogenous creatinine clearance) per se was directly correlated with maximal urinary flow and inversely correlated with the minimal urinary osmolar concentration achieved during water diuresis.