ANTIOXIDANTS AS AGENTS REDUCING THE TOXICITY OF INDOMETHACIN
- 1 January 1980
- journal article
- research article
- Vol. 39 (6) , 717-721
Abstract
Simultaneous oral administration of butylhydroxytoluene (BHT) (50 or 100 mg/kg) with indomethacin [a nonsteroidal anti-inflammatory agent, IND] (3, 6 or 20 mg/kg) prevented the damaging effect of IND on the rat gastric mucosa. Butylhydroxyanisole and nordihydroguiaretic acid rather potentiated than prevented the noxious action of IND. A reduction of IND toxicity without affecting its anti-inflammatory action may be possible by concomitant administration of IND with BHT.This publication has 5 references indexed in Scilit:
- Differential inhibitory effects of vitamin E and other antioxidants on prostaglandin synthetase, platelet aggregation and lipoxidaseProstaglandins, 1977
- A lipid peroxide inhibits the enzyme in blood vessel microsomes that generates from prostaglandin endoperoxides the substance (prostaglandin X) which prevents platelet aggregationProstaglandins, 1976
- Arterial walls are protected against deposition of platelet thrombi by a substance (prostaglandin X) which they make from prostaglandin endoperoxidesProstaglandins, 1976
- ANTIOXIDANTS AS AGENTS POTENTIATING ANTIINFLAMMATORY ACTION OF INDOMETHACIN1976
- Effect of temperature and antioxidants upon the lipoxidase-catalyzed oxidation of sodium linoleateArchives of Biochemistry and Biophysics, 1953