THE UTILIZATION OF ACETATE BY LIVER AND ADIPOSE TISSUE OF GROWTH HORMONE TREATED RATS OF DIFFERENT AGES

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Abstract
The effect of growth hormone on the in vitro incorporation of Cl4 acetate into fatty acids, carbon dioxide, and cholesterol by liver and adipose tissue from young, adult, and old rats was studied. In all three age groups of animals, growth hormone was found to de -press the incorporation of acetate into fatty acids by liver slices but the CO2 production was unaffected. In both young and old animals growth hormone did not significantly alter the incorporation of acetate into fatty acids and CO2 by preparations of adipose tissue, but did result in a decline in the fat content of the adipose tissue. It was noted that the CO2 production from acetate was much less with adipose tissue from old rats than with similar preparations from young rats. Incorporation of acetate into cholesterol was unaffected by growth hormone in young and old animals but was significantly increased in liver slices from adult animals.