Scintillation Proximity Assay as a High-Throughput Method to Identify Slowly Dissociating Nonpeptide Ligand Binding to the GnRH Receptor

This publication has 13 references indexed in Scilit:

• Kinetics of nonpeptide antagonist binding to the human gonadotropin-releasing hormone receptor: Implications for structure–activity relationships and insurmountable antagonism
  Biochemical Pharmacology, 2006
• Drug–target residence time and its implications for lead optimization
  Nature Reviews Drug Discovery, 2006
• Slow antagonist dissociation and long-lasting in vivo receptor protection
  Trends in Pharmacological Sciences, 2006
• Biochemical Mechanisms of New Molecular Entities (NMEs) Approved by United States FDA During 2001-2004: Mechanisms Leading to Optimal Efficacy and Safety
  Current Topics in Medicinal Chemistry, 2006
• Biochemical mechanisms of drug action: what does it take for success?
  Nature Reviews Drug Discovery, 2004
• Biological Characterization of a Novel, Orally Active Small Molecule Gonadotropin-Releasing Hormone (GnRH) Antagonist Using Castrated and Intact Rats
  The Journal of Pharmacology and Experimental Therapeutics, 2003
• A novel synthesis of 7-aryl-8-fluoro-pyrrolo[1,2-a]pyrimid-4-ones as potent, stable GnRH receptor antagonists
  Bioorganic & Medicinal Chemistry Letters, 2002
• Antihypertensive Efficacy of Candesartan in Comparison to Losartan: The CLAIM Study
  The Journal of Clinical Hypertension, 2001
• Angiotensin II type 1 receptor antagonists
  Biochemical Pharmacology, 2000
• A comparison of the efficacy and duration of action of candesartan cilexetil and losartan as assessed by clinic and ambulatory blood pressure after a missed dose, in truly hypertensive patients A placebo-controlled, forced titration study
  American Journal of Hypertension, 1999