An Accelerator of Prothrombin Activation Derived From Prothrombin

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Abstract
When purified prothrombin is dissolved in 25% sodium citrate solution it is first transformed to a derivative which does not yield thrombin with the two-stage analytical reagents used for the quantitative determination of prothrombin activity. The derivative accelerates the activation of purified prothrombin in the presence of thromboplastin, Ac-globulin and Ca ions. Later the derivative transforms to thrombin and then no longer possesses accelerator properties. The derivative is called citrate autoprothrombin.