The Role of Enzyme in Reversible Agglutination of Red Cells

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Abstract
Summary: It is suggested that the reversible agglutination of trypsin-treated red cells is related to trypsin-antitrypsin activity rather than to submerged antigens in the cell and preexisting specific antibody in the homologous serum. If the tendency toward reversible agglutination of trypsin-treated cells is responsible for false positive reactions in grouping and cross-matching, it seems that papain might be a preferable enzyme, since it has been found that papain-treated cells do not show the phenomenon of reversible agglutination.