THE PRODUCTION OF IMMUNO-CONGLUTININ: III. FACTORS AFFECTING THE RESPONSE TO AUTOSTIMULATION IN MICE

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Abstract
A number of carbohydrates, proteins, bacteria, and other substances with biophysically active surfaces were injected into mice to find which type of substances or surfaces stimulated the production of immuno-conglutinin by auto-stimulation. Mice injected with a variety of compounds which have different antigenic properties, as well as certain substances with absorptive surfaces, produced immuno-conglutinin. The data reported are in agreement with the hypothesis that immuno-conglutinin (autostimulation) is an autoantibody and that adsorbed complement is its specific-stimulating antigen.