HISTOPATHOLOGY OF SPONTANEOUS REGRESSION IN VIRUS-INDUCED MURINE LEUKEMIA

  • 1 January 1976
    • journal article
    • research article
    • Vol. 85  (1) , 73-84
Abstract
The histopathology of the spontaneous regression of murine leukemia induced by a particular strain of Friend leukemia virus was studied in Swiss ICR/Ha mice. Animals inoculated with the regressing strain of Friend virus exhibited an initial pathologic response identical to that induced by conventional strains of Friend virus. Unlike the fatal leukemia produced by conventional Friend virus, the pathology of the disease induced by the regressing strain of Friend virus appeared to be self limiting. The histopathology of the 2 diseases is compared in this report. [The immune response is involved in tumor regression.].