STUDIES ON THE MECHANISM OF THE LUPUS ERYTHEMATOSUS (L.E.) PHENOMENON*

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Abstract
Studies on the lupus erythematus (LE) phenomenon have shown that in addition to LE factor, nuclei, and normal leukocytes, an accessory serum factor present in normal serum is necessary for the LE phenomenon. This accessory serum factor is believed to be necessary for the phagocytosis of nuclear material which has been specifically altered by reaction with LE factor. The reaction of fluorescent labeled lupus gamma globulin with nuclei has been quantitatively studied and evidence for the heterogeneity of the LE factor in various patients has been obtained.