Lymphocyte subpopulations in the cerebrospinal fluid and peripheral blood in multiple sclerosis

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Abstract
Lymphocyte subpopulations in the CSF and peripheral blood were studied in 30 patients with multiple sclerosis (MS), 16 with other neurological diseases (OND) and 15 control subjects with no neurological abnormalities. In patients with MS relapse the absolute numbers of total lymphocytes, .alpha.-naphthyl acid esterase (ANAE) positive, E-rosette forming and bearing the avid FcIgG receptor lymphocytes were significantly increased in the CSF as compared with stable or slowly progressive MS patients, patients with other OND and control subjects. The relative number of ANAE-positive cells was higher, and avid FcIgG receptor bearing cells were lower in the CSF of all patients with MS than in the 2 other groups. The significance of the finding is unclear. The imbalance between lymphocyte subpopulations may reflect a primary defect in MS or may be secondary, due to the presence of circulating immune complexes. In peripheral blood no substantial differences in lymphocyte behavior were observed between MS patients and other groups.