INHIBITION OF GH1 RAT PITUITARY TUMOR-CELL ADENYLYL CYCLASE ACTIVITY BY SOMATOSTATIN
- 1 January 1978
- journal article
- research article
- Vol. 4 (6) , 453-462
Abstract
Somatostatin inhibits basal and chlorpromazine stimulated adenylate cyclase activity in homogenates of GH1 rat pituitary tumor cells. The DTrp8-DCys14 analog was more potent than tyrosyl somatostatin as an inhibitor of both basal and chlorpromazine-stimulated adenylate cyclase. Somatostatin had no effect on NaF or guanylyl-imidodiphosphate-stimulated cyclase in GH1 cell homogenates or on basal, epinephrine or prostaglandin E1 stimulated cyclase activity in sonicated BHK [baby hamster kidney] fibroblasts. A specific effect of somatostatin to inhibit pituitary adenylate cyclase activity is indicated.This publication has 6 references indexed in Scilit:
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