Recombinations defining centromeric and telomeric borders for the hereditary haemochromatosis locus.
Open Access
- 1 January 1997
- journal article
- Published by BMJ in Journal of Medical Genetics
- Vol. 34 (1) , 28-33
- https://doi.org/10.1136/jmg.34.1.28
Abstract
Hereditary haemochromatosis (HFE) is a common inherited disorder, affecting approximately five per thousand white people of northern European descent. Genetic linkage and linkage disequilibrium studies indicate that the disease locus is tightly linked to HLA-A and D6S105. Recombination between HFE and HLA class I loci is known to be rare. We report here two pedigrees in which recombinations telomeric of HLA-A occurred. These recombinant events define new centromeric and telomeric borders for the HFE locus.Keywords
This publication has 21 references indexed in Scilit:
- Characterization of a recombinant that locates the hereditary hemochromatosis gene telomeric to HLA-FHuman Genetics, 1995
- Allelic associations and homozygosity at loci from HLA-B to D6S299 in genetic haemochromatosis.Journal of Medical Genetics, 1995
- Recombination rates across the HLA complex: use of microsatellites as a rapid screen for recombinant chromosomesHuman Molecular Genetics, 1995
- The 1993–94 Généthon human genetic linkage mapNature Genetics, 1994
- Alleles at D6S265 and D6S105 define a haemochromatosis‐specific genotypeBritish Journal of Haematology, 1994
- Mapping recombinant events with molecular markers in hemochromatosis pedigreesCytogenetic and Genome Research, 1994
- Prevalence of Hemochromatosis among 11,065 Presumably Healthy Blood DonorsNew England Journal of Medicine, 1988
- Polymorphic DNA region adjacent to the 5' end of the human insulin gene.Proceedings of the National Academy of Sciences, 1981
- Hereditary HemochromatosisNew England Journal of Medicine, 1977
- Association of HLA-A3 and HLA-B14 antigens with idiopathic haemochromatosis.Gut, 1976