Digoxin “receptors” in neonates: An explanation of less sensitivity to digoxin than in adults

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Abstract
To investigate the possibility of altered digoxin receptor binding properties in neonates, digoxin binding with erythrocytes from neonates and adults were compared. Neonatal erythrocytes had 2 1/2 times as many digoxin binding sites as adult erythrocytes. The neonatal receptors had Kd for digoxin that were twice the adult value. Differences in binding properties may explain the clinical observation of decreased sensitivity to digoxin in neonates and infants.