Conversion of Porphobilinogen to Porphyrin by Liver Homogenates of Rats with Experimental Hepatic Porphyria.

Publisher Website
Google Scholar
Abstract
Liver homogenates prepared from rats with experimental porphyria induced by treatment with allyl-isopropyl-acetylcarbamide converted porphobilinogen to porphyrins at the same rate as did those prepared from normal rats. It is suggested that excessive porphobilinogen in the liver and urine of treated rats is due to its overproduction and not a defect in its further metabolism. A quantitative procedure for the analysis of liver porphobilinogen is described.