Conversion of Porphobilinogen to Porphyrins by Normal Rat Liver Homogenate.

Abstract
At least 11 different porphyrins were obtained following incubation of normal rat liver homogenate with porphobilinogen for 0.5 to 22 hours. Copro-, proto-, and uroporphyrins (chiefly type III isomer) predominated, being present in the homogenate chiefly as non-fluorescing porphyrinogens. The overall yield as porphyrin was more than 50% in each of the incubated samples.